The paper deals with the problem of qualia in the context of Umberto Eco‘s semiotics. I propose that Eco started to focus specifically on the problem of qualia mostly in his later period when he turned from the idea of almost universal theory of semiotics (e.g., in Theory of Semiotics) to cognitive realism (in Kant and the Platypus) with the help of more precise reinterpretation of Peirce’s concepts. Eco’s view of the problem of qualia is closely connected to his understanding of cognitive processes of understanding leading from cognitive type to molar content – understanding qualia as “semiosis primes,” which are the fundamental base of the possibility of all signification, therefore as a base of cognitive types. On the other hand, qualia are considered to be a base of cognitive types; thus we should regard them as having every-day communicative character. Therefore, the aim of this paper is to explore this specific two-fold understanding of qualia in the context of Eco’s and Peirce’s semiotic.