The paper address the question of whether quantum mechanics (QM) favors Priority Monism, the view according to which the Universe is the only fundamental object. It develops formal frameworks to frame rigorously the question of fundamental mereology and its answers, namely (Priority) Pluralism and Monism. It then reconstructs the quantum mechanical argument in favor of the latter and provides a detailed and thorough criticism of it that sheds furthermore new light on the relation between parthood, composition and fundamentality in QM.