The aim of this article is to compare the concept of Immanence, or rather, the definition of "plane of Immanence" as described and invented by Deleuze (and Deleuze and Guattari) with the concept of Individuation (in Simondon, but also within a long philosophical tradition from medieval philosophy to Leibniz, as discussed also by Deleuze, as it is well known). The article will also consider the possible consequences of this investigation on semiotic research regarding: (1) the building of meaning processes; and (2) possible connections with other areas of social and human sciences (such as the Theory of Systems).