The current crisis, which not least is a crisis of reason, requires to be traced back historically to the dualistic-epistemic concept of Enlightenment. By following the here delineated revision of the "Old Enlightenment", often called "Modernity", the study will emphasize the vital necessity to pave the way for new approaches towards an Enlightenment which will have to be based on cross-culturality. Above all, regaining an understanding of Oneness is a challenge for a new vision, which likewise unifies spiritual wisdom with precise knowledge. Regarding especially the process of the individuation of the Divine, I will focus on the universal (^cAql al-Kullî) reason in the structure of knowledge in the opus of Ikhwan as-Safa and the Logos of Life in the philosophy of Anna-Teresa Tymieniecka. It shall be argued that with Ikhwan as-Safa the individuation of the principle of life found its earliest encyclopedic expression. The Logos of Life philosophy brings the current level of sciences into harmony with the moral sensitivity directing the communicative web of everything-there-is-alive.